We propose to use the ISO Long Wavelength Spectrometer (LWS) to measure the line intensities of several high-J 12CO, 13CO and C18O rotational lines in different massive star formation regions. Theoretical calculations for UV-heated high density molecular clouds result in a large amount of hot CO. Therefore, even the high rotational lines are excited and should be detectable. A detection of these lines results in detailed information on the still unknown excitation conditions for these high-J lines. As especially the intensities of the high-J CO lines depend sensitively on the hydrogen particle density and UV-field strength, these lines are an excellent tool to determine the physical conditions. The chemical composition and isotopic CO abundance ratios will be estimated using the isotopic CO line intensities.