The lowest-lying excited rotational states of water can only be appreciably excited in the warmest, densest molecular clouds and cloud cores. Molecular clouds in the region of the Galactic Center are particularly warm, so collisions with H2 molecules are sufficiently energetic throughout the clouds there to populate those low-lying levels and to thereby give rise to observable far-IR line emission. We propose to observe four far-IR lines of water in galactic center clouds in order to: (1) determine the gas-phase water abundance in these clouds, (2) provide an independent measure of the cloud kinetic temperature using line ratios, and (3) infer the relative importance of water in the unusual thermal balance of these clouds. This would represent the first concerted effort to study water in the Galactic center cloud population. Because the lines of interest occur in the far-infrared between 100 and 200 microns, they can only be observed with ISO and with the Kuiper Airborne Observatory (KAO). If the KAO continues operating beyond the 1994-95 season, this project would require multiple flights out of New Zealand, which NASA will be reluctant to grant because of the inordinate expense of operating there. In addition, the time required to measure four relatively weak lines in as many as 8 sources with the KAO is prohibitive, whereas it becomes a relatively routine observation for ISO.